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242 The vitamin D/VDR axis has been shown to suppress the overexpression of HIF-1 in colonic epithelial cells by regulating the NF-B pathway, thereby inhibiting the overexpression of inflammatory factors
Ravulizumab, also a humanized anti-C5 mAb, was the trial drug in the CHAMPION trial in 2022, which also enrolled adult patients
Few user reviews mention this mechanism, but it explains why the drug's liver benefits persist long-term in a way that simple ALT-lowering agents may not
The PIONEER studies used similar main endpoints
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