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When glutathione levels drop, the immune system effectively "loses its brakes," allowing for the overproduction of pro-inflammatory cytokines like Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-)
FIGURE 1 Given the scope of this review, we will summarize insulin actions on non-renal target organs, but detailed information is available in recent reviews (Tokarz et al., 2018)
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When activated, the Nrf2 pathway upregulates the expression of a wide range of genes that help to protect cells against various stressors such as reactive oxygen species (ROS), electrophiles, and xenobiotics
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