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The results are that -cell function was improved, and fasting glucagon levels were reduced in patients treated with TZP, better than dulaglutide, improving several markers of pancreatic -cell function, as exposed by dose-dependently decreasing proinsulin levels, proinsulin/insulin ratios and proinsulin/C-peptide ratios and increasing HOMA2-B indices

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Research has indicated that compounds targeting TRP channels, such as vanillin, capsaicin and capsazepine, can reduce reactive astrocyte activity, which in turn can mitigate A toxicity in the early stages of AD 154