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Common gastrointestinal side effects include: Nausea the most frequently reported side effect, particularly during dose escalation Vomiting often linked to nausea and typically dose-dependent Diarrhoea and constipation both have been reported, reflecting altered gut motility Decreased appetite a desired therapeutic effect, but one that requires monitoring to ensure adequate nutrition Severe or prolonged vomiting and diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)
In 2024, Lemonaid Health launched its own GLP-1 weight-management program, partly inspired by a 23andMe genetic study exploring why these medications work better for some people than others, and why some experience stronger side effects
Nevertheless, future studies with larger cohorts and granular data on agent dosing or short- vs
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