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Gorgojo-Martnez JJ, Mezquita-Raya P, Carretero-Gmez J, Castro A, Cebrin-Cuenca A, de Torres-Snchez A, Garca-de-Lucas MD, Nez J, Obaya JC, Soler MJ, Grriz JL, Rubio-Herrera M

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The figure connects the activation of GLP-1R to downstream pathways (cAMP/PKA, Epac/PI3K/Akt, AMPK/SIRT1, ERK/MAPK) that regulate mitochondrial function, autophagy, proteostasis, and stress response, all of which collectively influence the hallmarks of aging to improve both cellular and systemic resilience