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doi:10.2174/1389201019666180808163311 Schubert, Mitchell L, and David A Peura
At the receptor level, IGF-1 LR3 binds the IGF-1 receptor (IGF1R) and activates its intrinsic tyrosine kinase domain, which initiates downstream signaling through the PI3K/AKT and MAPK/ERK cascades
To estimate NADPH concentration in the sample before freezing, calculated value is added to the NADPH concentration measured in frozen sample
This is particularly relevant in the cancer context, where the tumor microenvironment often promotes oxidative stress and altered cellular signaling pathways, contributing to the rapid turnover of RBCs
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