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Elevated GIP levels and duodenal K cell hyperplasia (62) have also been reported in HFD-treated mice, while Gipr deficiency protects mice from HFD-, leptin deficiency- or ovariectomy-induced weight gain (63, 64)
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263 Similarly, in HCC, the oncofetal protein CLDN6 competes with TJP2 for YAP1 binding via its PDZ domain, displacing YAP1 from tight junctions and facilitating its nuclear localization
Aug 10: Janssen also won the FDAs accelerated approval for its first-in-class bispecific T cell engager Talvey (talquetamab) as a treatment for relapsed or refractory multiple myeloma
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