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Administration: Subcutaneous injection (abdomen, thighs, or upper arms) Typical dosing range: 2-5 mg per week, often split into two injections of 1,250-2,500 mcg during the loading phase Cycle length: Loading phase of 4-6 weeks at 4-8 mg/week, followed by a maintenance phase of 4-8 weeks at 2-2.5 mg/week

We validated this through SLC19A1 knockdown experiments, showing that transporter downregulation reverses folate-induced exhaustion, restoring T cell IFN- secretion and tumor-killing activity

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Designed solely for parenteral use (drug administration by intravenous, intramuscular, or subcutaneous following the addition of solutions that require dilution or must be dissolved in an aqueous vehicle prior