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It was more effectively activated by elevated levels of GSH in H1299 lung cancer cells than that in normal lung fibroblasts WI38 cells, releasing reactive alkoxyamines to capture AP sites, blocking APE1 repair, and leading to lung cancer cell death in vitro
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So while Zepbound typically causes a very mild resting heart rate increase of about 2.1 to 5.4 beats per minute, Retatrutide has shown a more noticeable average increase of 6.7 to 7 beats per minute
10.1016/j.bbrc.2007.09.018 6 BradfordM
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