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doi: 10.1016/j.jep.2022.115324 18 TanYYYueSRLuAPZhangLJiGLiuBCet al

The trial took place at an inpatient rehabilitation center where the patients were already receiving treatment with the option to take the OUD medication buprenorphine

This creates uncertainty over whether any observed laboratory response belongs to TB-500 itself or to a metabolite generated under specific conditions

Tesamorelin , a stabilized GHRH analog , binds the GHRH receptor on pituitary somatotrophs to stimulate endogenous growth hormone release and elevate IGF-1