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Besides, by upregulating the cytochrome c oxidase 2 (SCO2) (167), TP53 initiates several transcriptional programs to promote the expression of genes related to mitochondrial biogenesis (168), such as apoptosis-inducing factor (AIF) (169, 170) and ferredoxin reductase (FDXR) (171)

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Figure 6 presents the simulated fate of a single 50 M doxorubicin exposure (top panel), as well as the subsequent O 2 . and H 2 O 2 profiles, over a 30-minute time-span