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In human studies, long-term recreational ketamine use has been associated with structural brain changes, including reduced prefrontal gray matter volume and impaired white matter connectivity, which are potentially linked to chronic low-grade inflammation (Liao et al., 2011
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Patients were excluded if they had a prescription fill within 60 days after the date of discontinuation or if the GLP-1 RA indication (AOM or ADM) could not be determined
Morning use is recommended to maximise antioxidant protection throughout the day
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