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The SURMOUNT-1 trial enrolled over 2,500 participants and tested three dose levels against placebo over 72 weeks
High-sugar, high-fat (HSHF) diets significantly lead to an imbalance in the ratio of bacteria in the phylum Acidobacteria, Firmicutes and Thick-walled bacteria to those in the phylum Anaplasma, Aspergillus, Cyanobacteria, and Actinobacteria, which impairs the gut barrier function, and activates microglial cells in the brain, generating inflammation and affecting the cholinergic system to increase the risk of cognitive dysfunction (58, 59)
Eating bland foods, staying hydrated, and consuming smaller meals can help alleviate nausea
Among current treatments for T2D, GLP-1R agonists stand out as one of the most promising [55, 77,78,79]
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