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Numerous studies have demonstrated the therapeutic potential of phytomolecules in preclinical cellular and animal PD models, with their ability to exert pleiotropic neuroprotective effects by targeting, inflammatory signaling, mitochondrial dysfunction, S aggregation, and key pathways including sirtuins and PI3K/Akt signaling ( Future research should also aim to disentangle the mechanistic interplay between S accumulation, sirtuin dysregulation, and impaired insulin signaling in PD, to identify which phytomolecules are most effective in counteracting mitochondrial stress, mitophagy defects, and neuronal apoptosis

Baicalin targets HSP70/90 to regulate PKR/PI3K/AKT/eNOS signaling pathways

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HMOs are complex carbohydrates that are naturally found in human breast milk and have been shown to selectively stimulate beneficial bacteria, both directly and indirectly through mechanisms such as cross-feeding