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Messer finds she can bring them back to their baseline with a short course of semaglutide, and then wean them off the drug and leave them to their own devices. Likewise, many aesthetics patients use the diabetic shot for weight loss for a limited stretch, according to the doctors we interviewed
(NEJM 2023), where retatrutide 12 mg produced 24.2% mean body-weight loss at 48 weeks without a plateau [1]
"In patients with obesity, the use of orforglipron resulted in statistically and clinically significant weight reductions and an adverse-event profile that was consistent with findings regarding other GLP-1 receptor agonists," researchers concluded
Benefits depend on eligibility, medication response, adherence and lifestyle factors
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