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In some countries hydroxocobalamin has completely replaced cyanocobalamin as first choice for vitamin B 12 therapy because it is retained in the body longer and can be administered at intervals of up to three months
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dose-for-dose equivalence is not 1:1 Dosing frequency is typically once or twice daily Storage requirements depend on the formulation and should be confirmed with the compounding partner Because dose is formulation-specific and compounding preparations vary, physicians should work with their compounding partner to confirm the specific dose and protocol appropriate to the formulation they prescribe
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