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NFE2L2 (NRF2): The Master Transcriptional Regulator Every gene discussed above GCLC, GCLM, GSR, GPX1, GSTM1, GSTT1 has antioxidant response element (ARE) sequences in its promoter that are activated by the transcription factor NRF2 , encoded by NFE2L2
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Studies show NAC supplementation helps reduce depressive symptoms when added to standard antidepressant medications for better mood stability
Therefore, FOXO4-DRI's targeted mechanism suggests a potential research outcome by facilitating the removal of senescent cells, which may contribute to tissue rejuvenation and improved organ function while still preserving the critical antioxidant defenses mediated by FOXO4
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