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Lv C, Zhang Y, Shen L

These are often essential

[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)

Nickel JC, Moldwin R, Lee S et al: Intravesical alkalinized lidocaine (psd597) offers sustained relief from symptoms of interstitial cystitis and painful bladder syndrome