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GLP-1 receptor agonism promotes insulin secretion in a glucose-dependent manner, reduces appetite, and slows gastric emptying
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The 27G needle had the best balance: injection time under 20 seconds for 1 mL, leakage rate 3.2%, and patient pain scores equivalent to 30G
In the weight management trials using semaglutide 2.4 mg, approximately 44% of participants experienced nausea at some point during treatment compared to 16% receiving placebo
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