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The systematic review included a search of PubMed, Embase, Web of Science, ClinicalTrials.gov, and Cochrane Library
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Tirzepatide activates two hormone pathways: GLP-1 (glucagon-like peptide-1) This hormone helps signal fullness, slows stomach emptying, and supports healthy insulin response after meals
These results indicate that downregulation of the PPARa pathway reduces FABP1 expression, leading to alterations in GPX4 and ACSL4 levels that contribute to HMC ferroptosis and IgAN pathogenesis [161]
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