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Its core advantages are mainly reflected in three aspects: first, VS can efficiently process massive compound databases, screening far more compounds than traditional methods
Next, PPAT, a NRF2-regulated enzyme [59], catalyzes the displacement of the pyrophosphate with an amide nitrogen from glutamine
Under hypoxic or hyperglycemic conditions, the accumulation of HIF1 markedly drives renal tubular cell ferroptosischaracterized by HO1/TFRC upregulation, iron overload, and lipid peroxidation
Archived from the original on 16 August 2016
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