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Wegovy contains semaglutide and targets the GLP-1 hormone, while Mounjaro contains tirzepatide and targets both GLP-1 and GIP
Enteroendocrine cells (EECs), the microbiota, and metabolites produced by the microbiota constitute a complex signaling system [13] that involves the enteric plexus, CNS afferents and efferents, and the modulation of numerous brain nuclei like the nucleus tractus solitarius, hypothalamus, thalamus, and many others directly involved in the control of glucose and energy homeostasis [14]
Figure 11 Inflammation is an established risk factor for CV disease (238)
Such antisteatotic and metabolic effects of GLP-1 on the liver could involve AMPK activation and suppression of the mTOR pathway
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