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Higher doses are associated with greater appetite suppression and more pronounced gastrointestinal effects, both of which can prolong fatigue
Furthermore, recent studies have demonstrated that GLP-1RAs may exert their anorexigenic effects not only by acting on ARC POMC neurons but also in other brain regions, such as the dorsomedial hypothalamus (DMH) and the dorsal vagal complex in the hindbrain [8, 9]
Disadvantages include less predictable absorption, potential variability between doses, and the need for strict technique (holding the drops under the tongue for 60-90 seconds without swallowing)
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