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(116) to clarify the causality between the gut microbiota and musculoskeletal disorders restricted the scope of orthopedic pathologies to six musculoskeletal diseases that may be highly associated with the gutbone axis: osteoporosis, fracture, myasthenia gravis, low back pain (LBP), rheumatoid arthritis (RA), and ankylosing spondylitis
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(8) Additionally, Frag 176-191 may inhibit acetyl-CoA carboxylase, an enzyme associated with fatty acid synthesis, potentially limiting new adipose accumulation
Uma das falhas apontadas pelos autores do estudo foi a falta de dosagens dos nveis sricos e urinrios de carnitina, embora rpida depleo tecidual e srica e aumento da excreo urinria tenham sido demonstrados em estudos semelhantes
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