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Individuals with conditions impairing B12 absorption, such as pernicious anemia or gastrointestinal disorders
As noted above, the Yoon 2021 study identified an Akkermansia protein that stimulates GLP-1 release in mice and cells, and the Grasset 2017 study showed that disrupting the microbiome can impair GLP-1 signaling in mice
The number of layers in the skin remains unchanged though
This discovery also paved the path to additional GLP-1 agonists, like tirzepatide , a dual agonist that targets both GLP-1 and GIP receptors for even greater metabolic impact
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