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This could be due to the limited utilization capacity in the transport and delivery of vitamin E into the brain (Spector and Johanson 2007)

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Brain 17 , 81 (2024)

Encouraged by the gain-of-function from Glu72Arg, we searched for additional mutations enriched during the evolution of X(PC4) phages on the GD_M substrate (Supplementary Table 5) with the goal of improving activity so that proteolysis would be detectable in mammalian cells