gliptin and glp 1 Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus Cardiovascular effects of gliptins |

R., Duan, L., Greco, A., Huang, C., Soofi, S., Bandsma, R

dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

Figure 2E] was significantly higher than the placebo group at baseline

Avoiding excessive alcohol, smoke, and secondhand smoke is a great place to start