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In small proof-of-concept phase 2 randomized controlled trials (RCTs) in patients with biopsy-confirmed MASH, liraglutide at 1.8 mg/day for 48 weeks (201), semaglutide at 0.4 mg/day for 72 weeks (202), and tirzepatide at 15 mg/week for 52 weeks (203) have been reported to achieve placebo-corrected percentages of participants meeting the criteria for resolution of MASH without worsening fibrosis by 30% (P = 0.019), 42% (P 10%) may lead to diabetes remission (237)
They accumulate in the liver and have been linked to liver cancer and immunosuppression
Recent good quality research by Tolbert and Findling found that B6 and magnesium did not result in statistically significant effects
People currently using private 2.4mg weekly semaglutide injections may be able to move directly to 25mg daily tablets
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