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The specificity of the response was determined by treatment with an IGF-1R specific inhibitor, Picropodophyllin (PPP) that showed reduced BCL2 levels in GNE knockdown cells indicative of apoptotic response (Fig
It has a more sustained effect on plasma L-arginine levels than oral L-arginine alone, improving bioavailability and endothelial function
It is not intended or approved for human or veterinary use
Oral capsules are also common but may have lower bioavailability
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