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Examination and initial investigations Recommended minimum evaluation for new or worsening vaginal symptoms in a semaglutide-treated patient generally mirrors standard care: External vulvar inspection for dermatoses (lichen sclerosus, eczema/contact dermatitis), fissures, atrophy signs
Using plain sterile water creates an unbuffered solution vulnerable to pH drift from CO2 absorption, which accelerates degradation through acid- or base-catalyzed hydrolysis depending on the drift direction
Research has also shown that semaglutide does not permeate the blood-brain barrier, the layer that insulates the brain, protecting it from external agents
No side effects were reported, and some patients felt better within just 2 weeks
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