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They were developed on the basis of either human GLP-1 or exendin-4, a 39-amino acid peptide isolated from the Gila monster ( Heloderma suspectum ) venom, which shares 53% homology with GLP-1 [38]
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Each of its four components targets a different bottleneck in the repair-and-remodel cascade: GHK-Cu drives extracellular-matrix remodeling and copper delivery, BPC-157 supports angiogenesis (new blood-vessel formation) and blood flow, TB-500 (a thymosin beta-4 fragment) promotes cell migration and actin regulation, and KPV is an anti-inflammatory tripeptide
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