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The biology underlying both appears to be the same: a shared pathway, with one medication class affecting it
Fracture Risk Data from GLP1 Trials Several cardiovascular outcomes trials (CVOTs) have collected fracture data as secondary outcomes: Trials involving semaglutide and dulaglutide generally report fracture rates similar to placebo A few studies suggest a potential increase in non-vertebral fractures, though findings are inconsistent and often not statistically significant One important confounder is weight loss, which itself can lead to bone loss
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More research efforts are needed to guide dose adjustments and identify the optimal duration of holding GLP-1 RAs prior to scheduling EGD procedures
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