Not only that but you end up with increased amounts of oxidants which have been linked to accelerate the ageing process
(2018) showed that compared to wild-type mice, SHANK3- and SHANK2-knockout mice had fewer glutamate receptors in the striatum and thalamus regions, while CNTN4 knock-out mice had fewer glutamate receptors in the cortex and hippocampus regions [60]
Konig SA, Siemes H, Blaker F, Boenigk E, Gross-Selbeck G, Hanefeld F, Haas N, Kohler B, Koelfen W, Korinthenberg R: Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities
The methylation cycle, it turns out, is involved in many regulatory processes and genetic defects that can be particularly damaging