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In pregnant rats given twice daily subcutaneous doses of 2, 20, or 200 mcg/kg from gestation day 6 through lactation, decreases in maternal body weight, food consumption, and motor activity were observed at all doses
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In the subgroup analysis based on L-carnitine dose, when the treatment dose was more than 1 g/d, fasting blood glucose, triglycerides, and high-density lipoprotein-cholesterol were significantly improved
Tirzepatide decreases oral contraceptive exposure by about 20%, which increases the risk of pregnancy
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