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Researchers continue to investigate its influence on dermal papilla cell signaling, extracellular matrix regulation, angiogenic signaling, and the biological pathways that support normal hair follicle function and skin physiology

However, it is unclear whether the polymorphism of MTHFR could be an independent or an add-on risk factor for specific psychiatric symptoms, such as anxiety, depression, positive, or negative symptoms of schizophrenia, or acts as risk factor for specific psychiatric disorders, such as schizophrenia, major depression, autisms, and bipolar disorders

Functional medicine views the issue as dysregulated signaling rather than a simple excess-or-deficiency problem