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Additionally, semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Patients should seek medical evaluation for severe pain after injury, inability to bear weight, major swelling, deformity, numbness, weakness, fever, signs of infection, worsening abdominal pain, blood in stool, persistent vomiting, chest pain, shortness of breath, or neurological symptoms

These requirements become a source of barriers to many people in terms of geography, cost, scheduling, or provider availability