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doi: 10.2337/dc15-1518 91 CoronaGGiagulliVAMaseroliEVignozziLAversaAZitzmannMet al

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When the gut lining is inflamed and permeable, neurotransmitter production is disrupted, inflammatory cytokines cross into systemic circulation and reach the brain, and the vagus nerve the primary communication cable between gut and brain transmits distress signals that manifest as anxiety, brain fog, and fatigue