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Given this, combination treatment between b-AP15 and two well studied IAP antagonists that target XIAP, Tolinapant and Xevinapant, was mildly synergistic in HNSCC cells, demonstrating decreased colony formation potential and increased apoptosis (Fig
A healthy, unstressed cell maintains a vast majority of its glutathione pool in the reduced state, typically sustaining a GSH-to-GSSG ratio of greater than 10:1, and often up to 100:1 in the cytosol
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Arachidonic acid- (AA-) containing phosphatidylethanolamine (PE) and adrenic acid- (AdA-) containing PE were previously identified as the primary substrates for lipid peroxidation (Kagan et al., 2020), but mounting evidence raises doubts about this mechanism since a range of polyunsaturated fatty acids (PUFAs) may be implicated in ferroptosis (Zheng and Conrad, 2020)
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