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We used the search terms fracture, osteoporosis, semaglutide, calorie restriction, bariatric surgery, bone density, bone turnover markers, liraglutide, tirzepatide, Glucagon-like peptide 1, and glucagon-like peptide receptor analogues in combination with the terms obesity and diabetes

The findings, published in the Lancet, suggest drugs could have wider benefits for patients beyond weight loss so should not be restricted to the most obese patients

Clinical trials show that participants who maintain therapeutic tirzepatide doses continue losing weight or keep weight off, with some studies reporting sustained benefits at 68-week follow-ups