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In this promising context, the likely availability in the near future of drugs for T2D at dosages equal to those used in obesity and with average weight reduction of 20% compared to baseline, such as tirzepatide 15 mg [77], oral semaglutide 50 mg [54], CagriSema 2.4/2.4 mg [82], will compellingly raise the issue of first-line treatment of patients with T2D, which should clearly be addressed to the fundamental pathogenetic moment of T2D, namely the increase in adiposity

Genetic instruments for T2D and SA Genetic variants significantly associated with T2D and SA at a genome-wide significance level (p 0.05) (Fig