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An independent assessment committee evaluated the endpoints and determined threshold criteria for clinically meaningful responses before the trials unblinding
Fatal outcomes documented at therapeutic doses: The first documented case of a pregnant woman dying from liver failure after taking normal, recommended doses of acetaminophen
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However, science is particularly interested in it because of its many physiological, endocrine and modulatory effects, such as its ability to alter corticotropin levels, inhibit somatostatin secretion, normalize blood pressure, reduce stress, influence sleep rhythms, or chronic pain perception
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