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Ca 2+ is not metabolized and an overload of mitochondrial Ca 2+ may break down the electrochemical proton gradient resulting in a deficit of ATP followed by necrosis [89]
10.1016/j.exer.2015.04.016 43 Medvidovic-GrubisicM.StambolijaV.KolencD.KatancicJ.MurselovicT.Plestina-BorjanI.et al (2017)
The study involved 9,340 patients with type 2 diabetes
Acknowledgements We thank Dr Robert Lefkowitz for insightful and helpful discussion
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