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Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma
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Many peptides exceed the optimal molecular weight threshold (500 Da) for skin penetration, and the partition coefficients (log P) are usually beyond the range required for effective absorption
Consequently, although current evidence strongly supports oxidative stress as a mediator of environmentally induced oocyte damage, we advocate conducting longitudinal human studies, mixture-based exposure analyses, and standardized exposure assessments to clarify the clinical relevance of these findings
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