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Usp8, identified as rhythmically expressed in the Drosophila brain and more specifically clock neurons, directly deubiquitinates Clock to suppress its transcriptional activity within the Clock-cycle complex, thereby reducing expression of target genes like per and tim ( Usp8 knockdown exhibited disrupted locomotor activity rhythms and displayed either arrhythmic or lengthened periods, displaying the role of Usp8 in maintaining circadian timing ( 4.2.8 USP9X and USP14 USP9X has been implicated in regulation of the positive arm of the molecular clock by deubiquitinating and stabilizing BMAL1 ( USP14 has been implicated in stabilizing PER proteins, as expression of a dominant-negative USP14 in HEK293 cells decreases levels of PER1 and PER2, and in MEFs leads to reduced PER2 half-life and a dose-dependent shortening of circadian period, indicating USP14s potential role in regulating the timing of the negative feedback loop ( Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinsons disease, suggesting it may modulate neurodegeneration-related disruptions in biological time ( 4.2.9 non-stop and Nipped-A non-stop (not

[Abstract]2025 Mar 25;16(1):201

GSH and GABA+) in the developing brain

Orijinal rnler nereden alnmal