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(PubMed) McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM

Every time someone jabs an Ozempic pen into their stomach, they're participating in one of the stranger origin stories in pharmaceutical history one that begins in the desert Southwest with a slow-moving, venomous lizard with a name like a nightmare

It is safest to take FDA-approved brand-name products (Ozempic, Wegovy, Rybelsus) made by Novo Nordisk

Within the hypothalamus, GLP-1 interacts with pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (it seems to have limited direct access here), a classic site involved in appetite regulation and energy expenditure