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An uncontrolled, open-label trial in nine patients with probable Alzheimers disease and related dementias, who were also taking acetylcholinesterase inhibitors, reported that oral supplementation with 600 mg/day of lipoic acid appeared to stabilize cognitive function over a one-year period (101)
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Upregulation of mGlu2 receptors via NF-kappaB p65 acetylation is involved in the Proneurogenic and antidepressant effects of acetyl-L-carnitine
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