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Among them, the effect of berberine on neurodegenerative diseases has received widespread attention, for example Alzheimers disease, Parkinsons disease, Huntingtons disease, and so on
Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]
Modulates lipid-synthesizing enzymes Some research suggests ALA may reduce the activity of key enzymes involved in fat production, including HMG-CoA reductase the same enzyme targeted by statin medications
27 , 690698.e4 (2019)
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