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The primary pathway involves amplification of glucose-triggered insulin production by pancreatic beta cells, which enhances adipose tissue nutrient uptake and reduces circulating free fatty acid flux to the liver [28]
Important safety information: GLP-1 medications carry an FDA boxed warning about thyroid C-cell tumors seen in animal studies and are contraindicated with a personal or family history of medullary thyroid carcinoma (MTC) or MEN2
AI can enable the design of novel drugs binding to the GLP-1 receptor and predicting their binding ability with the receptor
de Mesquita YLL et al
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