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Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics
Baum L, Ng A (2004) Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimers disease animal models
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Evidence: What We Can and Cant Say For most wellness goals (anti-aging, fat loss, muscle gain), rigorous human evidence is limited and outcomes are hard to separate from sleep, nutrition, training, and placebo effects
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