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Others may need medical nutrition therapy, obesity medicines, endoscopic options or bariatric surgery depending on their BMI, eating behaviour, diabetes status, sleep issues and long-term weight history

Safety and precautions: Because pure bacteriostatic water is hypotonic, it should not be injected alone intravenously (doing so can cause red cell hemolysis)

While no clinical trial has tested this combination, the anti-apoptotic and antioxidant effects of HIF-PHIs provide a strong mechanistic rationale for synergistic use with agents targeting erythrocyte apoptosis pathways (e.g., Bcl-xL upregulation or NIX inhibition)

Lauren Oshman, a University of Michigan Health physician who specializes in treating obesity